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10.1371/journal.pone.0135510 PLoS One 80 McElroyP

The energy stored in this gradient is then harnessed by ATP synthase (Complex V) to phosphorylate ADP into ATP ( Beyond energy conversion, mitochondria are indispensable for a myriad of other cellular processes, including heme and steroid hormone synthesis, calcium ion (Ca 2+ ) buffering to regulate intracellular signaling, and the initiation of apoptosis via the mitochondrial pathway ( Figure 1